Journal of Negative Results in BioMedicine

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		Research A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma Kevin Murphy, Sandra Gawchik, David Bernstein, Jens Andersen, Martin Rud Pedersen Journal of Negative Results in BioMedicine 2013, 12:10 (1 June 2013) Abstract \| Provisional PDF \| PubMed
		Research Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: a single-blind, placebo-controlled study in healthy subjects Gianluca Ivan Silvestrini, Franca Marino, Marco Cosentino Journal of Negative Results in BioMedicine 2013, 12:9 (25 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Brief report Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity Junaid Iqbal, Mehak Rajani, Ruqaiyyah Siddiqui, Naveed Ahmed Khan Journal of Negative Results in BioMedicine 2013, 12:8 (1 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Brief report Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation Andreas Kuehnl, Jaroslav Pelisek, Martin Bruckmeier, Wajima Safi, Hans-Henning Eckstein Journal of Negative Results in BioMedicine 2013, 12:7 (1 April 2013) Abstract \| Full text \| PDF \| PubMed
		Research Exclusion of eleven candidate genes for ocular melanosis in cairn terriers Paige A Winkler, Joshua T Bartoe, Celeste R Quinones, Patrick J Venta, Simon M Petersen-Jones Journal of Negative Results in BioMedicine 2013, 12:6 (1 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genotyping of eleven candidate genes for Ocular Melanosis in Cairn Terriers suggests they are unlikely to be the gene locus for this condition, highlighting the need for further study.
		Research Circulating rotaviral RNA in children with rotavirus antigenemia Kamruddin Ahmed, Gulendam Bozdayi, Marcelo T Mitui, Selim Ahmed, Luthful Kabir, Dalgic Buket, Ilknur Bostanci, Akira Nishizono Journal of Negative Results in BioMedicine 2013, 12:5 (1 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rotavirus (RVA) viremia was not found in children with rotavirus diarrhea, and could not be identified via the presence of antigenemia in the patients’ serum.
		Research Prolactin gene expression in primary central nervous system tumors Graziella Alebrant Mendes, Júlia Fernanda Semmelmann Pereira-Lima, Maria Beatriz Kohek, Geraldine Trott, Marlise Di Domenico, Nelson Pires Ferreira, Miriam da Costa Oliveira Journal of Negative Results in BioMedicine 2013, 12:4 (14 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Quantitative real-time polymerase chain reaction (PCR-RT) did not show prolactin expression in primary central nervous system tumors, suggesting that its presence is not a reflex of local production.
		Research Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods R Brad Jones, Fabio E Leal, Aaron M Hasenkrug, Aluisio C Segurado, Douglas F Nixon, Mario A Ostrowski, Esper G Kallas Journal of Negative Results in BioMedicine 2013, 12:3 (10 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The elicitation of human endogenous retrovirus (HERV)-specific T-cells responses may not have a role in human T-cell leukemia virus type 1 (HTLV-1) associated immunopathology suggests this study.
		Research Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis Luis P Andrade, Stewart M Rhind, Michael T Rae, Carol E Kyle, Jamie Jowett, Richard G Lea Journal of Negative Results in BioMedicine 2013, 12:2 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Brief report A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen Journal of Negative Results in BioMedicine 2013, 12:1 (2 January 2013) Abstract \| Full text \| PDF \| PubMed
		Brief report Absence of subtelomeric rearrangements in selected patients with mental retardation as assessed by multiprobe T FISH Suely Rodrigues dos Santos, Dértia Villalba Freire-Maia Journal of Negative Results in BioMedicine 2012, 11:16 (21 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with unexplained mental retardation (MR) and a chromosomal imbalance show an absence of subtelomeric rearrangements when assessed by Multiprobe T Fluorescence In-Situ Hybridization (MT FISH) probe.
		Research Could titanium oxide coating from a sol–gel process make stone baskets more resistant to laser radiation at 2.1 μm? Jens Cordes, Felix Nguyen, Frank Heidenau, Dieter Jocham Journal of Negative Results in BioMedicine 2012, 11:15 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The first attempt at making stone baskets more resistant to laser damage during endoscopic surgery did not result in greater resistance to laser radiation at 2.1 mum.
		Research Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury Inga Karu, Peeter Tähepõld, Arno Ruusalepp, Kersti Zilmer, Mihkel Zilmer, Joel Starkopf Journal of Negative Results in BioMedicine 2012, 11:14 (14 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pre-treatment with hyperoxia followed by normoxia before coronary artery bypass grafting does not protect against myocardial injury.
		Research No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg, Ansgar Espeland Journal of Negative Results in BioMedicine 2012, 11:13 (17 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research In vitro studies of the influence of glutamatergic agonists on the Na⁺,K⁺-ATPase and K⁺-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats Marcos Contó, Marco Antonio Venditti Journal of Negative Results in BioMedicine 2012, 11:12 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A better understanding is needed of the relationship between glutamatergic activation and enzymatic activity, suggests this study which finds that glutamatergic stimulation in rats does not influence Na+,K+-ATPase activity in the frontal lobe, the inhibition of which is associated with pathogenesis of epilepsy.
		Research Lifestyle counseling during pregnancy and offspring weight development until four years of age: follow-up study of a controlled trial Taina Mustila, Jani Raitanen, Päivi Keskinen, Antti Saari, Riitta Luoto Journal of Negative Results in BioMedicine 2012, 11:11 (8 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gestational lifestyle counseling does not significantly slow weight gain, proposes this pilot study which investigates risk of childhood obesity.
		Research Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE₂production by human gingival fibroblasts Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori, Hiroo Miyazawa Journal of Negative Results in BioMedicine 2012, 11:10 (27 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commonly prescribed for bronchial disorders, aminophylline does not adversely affect inflammatory response and exacerbate symptoms in periodontal disease at concentrations used in clinical settings unlike other PKA-inhibiting drugs.
		Research TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome Krishna K Singh, Joerg Schmidtke, Britta Keyser, Mine Arslan-Kirchner Journal of Negative Results in BioMedicine 2012, 11:9 (2 February 2012) Abstract \| Full text \| PDF \| PubMed
		Brief report Metallothionein genes: no association with Crohn's disease in a New Zealand population Angharad R Morgan, Alan G Fraser, Lynnette R Ferguson Journal of Negative Results in BioMedicine 2012, 11:8 (28 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population Ziad M Kanaan, Maurice R Eichenberger, Surriya Ahmad, Clayton Weller, Henry Roberts, Jianmin Pan, Shesh N Rai, Robert Petras, E Brooks Weller, Susan Galandiuk Journal of Negative Results in BioMedicine 2012, 11:7 (23 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is no association between OCTN1 and IGR SNPs and IBD (Inflammatory Bowel Disease), suggests this study which proposes a combined genetic, phenotypic and environmental approach to understand IBD.
		Research Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players Yongwoo Jang, Sung Min Kim Journal of Negative Results in BioMedicine 2012, 11:6 (12 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen, Yen-Ching Chen Journal of Negative Results in BioMedicine 2012, 11:5 (12 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy Diogo G Biagi, José G Mill, Alfredo J Mansur, José E Krieger, Alexandre C Pereira Journal of Negative Results in BioMedicine 2012, 11:4 (11 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research 5-Azacytidine Is Insufficient For Cardiogenesis In Human Adipose-Derived Stem Cells Wan Kamarul Zaman Wan Safwani, Suzana Makpol, Somasundaram Sathapan, Kien Chua Journal of Negative Results in BioMedicine 2012, 11:3 (6 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer Panagiotis J Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, Kassiani Kapatou, Ioannis Gioulbasanis, Danai D Daliani, George Moutzouris, Christos N Papandreou Journal of Negative Results in BioMedicine 2012, 11:2 (5 January 2012) Abstract \| Full text \| PDF \| PubMed

	All
		Research A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma Kevin Murphy, Sandra Gawchik, David Bernstein, Jens Andersen, Martin Rud Pedersen Journal of Negative Results in BioMedicine 2013, 12:10 (1 June 2013) Abstract \| Provisional PDF \| PubMed
		Research Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: a single-blind, placebo-controlled study in healthy subjects Gianluca Ivan Silvestrini, Franca Marino, Marco Cosentino Journal of Negative Results in BioMedicine 2013, 12:9 (25 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Brief report Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity Junaid Iqbal, Mehak Rajani, Ruqaiyyah Siddiqui, Naveed Ahmed Khan Journal of Negative Results in BioMedicine 2013, 12:8 (1 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Brief report Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation Andreas Kuehnl, Jaroslav Pelisek, Martin Bruckmeier, Wajima Safi, Hans-Henning Eckstein Journal of Negative Results in BioMedicine 2013, 12:7 (1 April 2013) Abstract \| Full text \| PDF \| PubMed
		Research Exclusion of eleven candidate genes for ocular melanosis in cairn terriers Paige A Winkler, Joshua T Bartoe, Celeste R Quinones, Patrick J Venta, Simon M Petersen-Jones Journal of Negative Results in BioMedicine 2013, 12:6 (1 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genotyping of eleven candidate genes for Ocular Melanosis in Cairn Terriers suggests they are unlikely to be the gene locus for this condition, highlighting the need for further study.
		Research Circulating rotaviral RNA in children with rotavirus antigenemia Kamruddin Ahmed, Gulendam Bozdayi, Marcelo T Mitui, Selim Ahmed, Luthful Kabir, Dalgic Buket, Ilknur Bostanci, Akira Nishizono Journal of Negative Results in BioMedicine 2013, 12:5 (1 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rotavirus (RVA) viremia was not found in children with rotavirus diarrhea, and could not be identified via the presence of antigenemia in the patients’ serum.
		Research Prolactin gene expression in primary central nervous system tumors Graziella Alebrant Mendes, Júlia Fernanda Semmelmann Pereira-Lima, Maria Beatriz Kohek, Geraldine Trott, Marlise Di Domenico, Nelson Pires Ferreira, Miriam da Costa Oliveira Journal of Negative Results in BioMedicine 2013, 12:4 (14 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Quantitative real-time polymerase chain reaction (PCR-RT) did not show prolactin expression in primary central nervous system tumors, suggesting that its presence is not a reflex of local production.
		Research Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods R Brad Jones, Fabio E Leal, Aaron M Hasenkrug, Aluisio C Segurado, Douglas F Nixon, Mario A Ostrowski, Esper G Kallas Journal of Negative Results in BioMedicine 2013, 12:3 (10 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The elicitation of human endogenous retrovirus (HERV)-specific T-cells responses may not have a role in human T-cell leukemia virus type 1 (HTLV-1) associated immunopathology suggests this study.
		Research Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis Luis P Andrade, Stewart M Rhind, Michael T Rae, Carol E Kyle, Jamie Jowett, Richard G Lea Journal of Negative Results in BioMedicine 2013, 12:2 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Brief report A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen Journal of Negative Results in BioMedicine 2013, 12:1 (2 January 2013) Abstract \| Full text \| PDF \| PubMed
		Brief report Absence of subtelomeric rearrangements in selected patients with mental retardation as assessed by multiprobe T FISH Suely Rodrigues dos Santos, Dértia Villalba Freire-Maia Journal of Negative Results in BioMedicine 2012, 11:16 (21 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with unexplained mental retardation (MR) and a chromosomal imbalance show an absence of subtelomeric rearrangements when assessed by Multiprobe T Fluorescence In-Situ Hybridization (MT FISH) probe.
		Research Could titanium oxide coating from a sol–gel process make stone baskets more resistant to laser radiation at 2.1 μm? Jens Cordes, Felix Nguyen, Frank Heidenau, Dieter Jocham Journal of Negative Results in BioMedicine 2012, 11:15 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The first attempt at making stone baskets more resistant to laser damage during endoscopic surgery did not result in greater resistance to laser radiation at 2.1 mum.
		Research Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury Inga Karu, Peeter Tähepõld, Arno Ruusalepp, Kersti Zilmer, Mihkel Zilmer, Joel Starkopf Journal of Negative Results in BioMedicine 2012, 11:14 (14 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pre-treatment with hyperoxia followed by normoxia before coronary artery bypass grafting does not protect against myocardial injury.
		Research No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg, Ansgar Espeland Journal of Negative Results in BioMedicine 2012, 11:13 (17 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research In vitro studies of the influence of glutamatergic agonists on the Na⁺,K⁺-ATPase and K⁺-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats Marcos Contó, Marco Antonio Venditti Journal of Negative Results in BioMedicine 2012, 11:12 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A better understanding is needed of the relationship between glutamatergic activation and enzymatic activity, suggests this study which finds that glutamatergic stimulation in rats does not influence Na+,K+-ATPase activity in the frontal lobe, the inhibition of which is associated with pathogenesis of epilepsy.
		Research Lifestyle counseling during pregnancy and offspring weight development until four years of age: follow-up study of a controlled trial Taina Mustila, Jani Raitanen, Päivi Keskinen, Antti Saari, Riitta Luoto Journal of Negative Results in BioMedicine 2012, 11:11 (8 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gestational lifestyle counseling does not significantly slow weight gain, proposes this pilot study which investigates risk of childhood obesity.
		Research Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE₂production by human gingival fibroblasts Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori, Hiroo Miyazawa Journal of Negative Results in BioMedicine 2012, 11:10 (27 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commonly prescribed for bronchial disorders, aminophylline does not adversely affect inflammatory response and exacerbate symptoms in periodontal disease at concentrations used in clinical settings unlike other PKA-inhibiting drugs.
		Research TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome Krishna K Singh, Joerg Schmidtke, Britta Keyser, Mine Arslan-Kirchner Journal of Negative Results in BioMedicine 2012, 11:9 (2 February 2012) Abstract \| Full text \| PDF \| PubMed
		Brief report Metallothionein genes: no association with Crohn's disease in a New Zealand population Angharad R Morgan, Alan G Fraser, Lynnette R Ferguson Journal of Negative Results in BioMedicine 2012, 11:8 (28 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population Ziad M Kanaan, Maurice R Eichenberger, Surriya Ahmad, Clayton Weller, Henry Roberts, Jianmin Pan, Shesh N Rai, Robert Petras, E Brooks Weller, Susan Galandiuk Journal of Negative Results in BioMedicine 2012, 11:7 (23 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is no association between OCTN1 and IGR SNPs and IBD (Inflammatory Bowel Disease), suggests this study which proposes a combined genetic, phenotypic and environmental approach to understand IBD.
		Research Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players Yongwoo Jang, Sung Min Kim Journal of Negative Results in BioMedicine 2012, 11:6 (12 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen, Yen-Ching Chen Journal of Negative Results in BioMedicine 2012, 11:5 (12 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy Diogo G Biagi, José G Mill, Alfredo J Mansur, José E Krieger, Alexandre C Pereira Journal of Negative Results in BioMedicine 2012, 11:4 (11 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research 5-Azacytidine Is Insufficient For Cardiogenesis In Human Adipose-Derived Stem Cells Wan Kamarul Zaman Wan Safwani, Suzana Makpol, Somasundaram Sathapan, Kien Chua Journal of Negative Results in BioMedicine 2012, 11:3 (6 January 2012) Abstract \| Full text \| PDF \| PubMed
		Research Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer Panagiotis J Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, Kassiani Kapatou, Ioannis Gioulbasanis, Danai D Daliani, George Moutzouris, Christos N Papandreou Journal of Negative Results in BioMedicine 2012, 11:2 (5 January 2012) Abstract \| Full text \| PDF \| PubMed