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No connection between the level of exposition to statins in the population and the incidence/mortality of acute myocardial infarction: An ecological study based on Sweden's municipalities

Staffan Nilsson12*, Sigvard Mölstad13, Catarina Karlberg3, Jan-Erik Karlsson4 and Lars-Göran Persson3

Author Affiliations

1 Division of Community Medicine, Department of Medicine and Health Sciences, Faculty of Health Sciences, Linköping University, S-581 83 Linköping, Sweden

2 Vikbolandet Health Care Centre, Department of Primary Health Care, County Council of Östergötland, Norrköping, Sweden

3 Unit of R&D in Primary Care, S-551 85 Jönköping, Sweden

4 Division of Cardiology, Department of Internal Medicine, Ryhov County Hospital, S-551 85 Jönköping, Sweden

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Journal of Negative Results in BioMedicine 2011, 10:6  doi:10.1186/1477-5751-10-6

Published: 24 May 2011

Abstract

Background

Randomised controlled trials have shown an excellent preventive effect of statins on ischemic heart disease. Our objective was to investigate if a relation can be detected between acute myocardial infarction- (AMI) mortality or incidence and statin utilisation, for men and women in different age-groups on a population basis.

Results

The utilisation rate of statins increased almost three times for both men and women between 1998 and 2002. During 1998-2000 the incidence of AMI decreased clearly for men but only slightly for women. Mortality decreased from 1998 to 2002. The change in statin utilisation from 1998 to 2000 showed no correlation to the change in AMI mortality from 2000 to 2002. Statin utilisation and AMI- incidence or mortality showed no correlations when adjusting for socio-economic deprivation, antidiabetic drugs and geographic coordinates.

Conclusions

Despite a widespread and increasing utilisation of statins, no correlation to the incidence or mortality of AMI could be detected. Other factors than increased statin treatment should be analysed especially when discussing the allocation of public resources.

Keywords:
Myocardial infarction; Incidence; Antilipemic agents; Sweden; Population; Ecological study