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Open Access Research

Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer

Panagiotis J Vlachostergios1*, Foteini Karasavvidou2, Grigorios Kakkas3, Kassiani Kapatou2, Ioannis Gioulbasanis1, Danai D Daliani1, George Moutzouris3 and Christos N Papandreou1

Author Affiliations

1 Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece

2 Department of Pathology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece

3 Department of Urology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece

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Journal of Negative Results in BioMedicine 2012, 11:2  doi:10.1186/1477-5751-11-2

Published: 5 January 2012

Abstract

Background

Loss of normal cell cycle control is an early event in the evolution of cancer. The expression of cyclin-dependent kinase (CDK) inhibitors p16 and p27 has been previously associated with progression of prostate cancer (PC). 70 patients diagnosed with early stage PCwere treated with radical prostatectomy (RP) at our institution and their tumor specimens were immunohistochemically evaluated for expression of p16 and p27. Available clinical data of time to PSA recurrence were correlated with the examined parameters and combined with pre-operative PSA level, Gleason score and pathological TNM (pT) stage assessment.

Results

Nuclear overexpression of p16 was not associated with time to biochemical failure (BF) (p = 0.572). Same was the case for nuclear p27 overexpression (p = 1.000). Also, no significant correlations were found between either p16 or p27, and pre-operative PSA level, pT stage and Gleason grade. pT stage emerged as the only independent prognostic factor for biochemical recurrence (p = 0.01).

Conclusions

These data question previously reported data supporting the prognostic relevance of both p16 and p27 proteins in early PC.