Table 5 |
||||
|
Multivariable Logistic Regression Analysis for UC vs. CD |
||||
|
Genetic and Clinical Variables |
Ulcerative Colitis vs. Crohn's Disease |
|||
|
|
||||
|
Estimate* |
p-value |
OR (95% CI) |
||
|
|
||||
|
Age at time of diagnosis |
≥ 27 |
0.32 |
0.04 |
1.38 (1.02-1.87) |
|
|
||||
|
< 27 |
0 |
|||
|
|
||||
|
Gender |
Female |
-0.38 |
0.01 |
0.68 (0.50-0.92) |
|
|
||||
|
Male |
0 |
|||
|
|
||||
|
Smoker Status |
Current |
-1.63 |
< 0.0001 |
0.20 (0.13-0.30) |
|
|
||||
|
Former |
-0.81 |
< 0.0001 |
0.45 (0.32-0.63) |
|
|
|
||||
|
Never |
0 |
< 0.0001 |
||
|
|
||||
|
Number of Operations |
Yes |
-0.63 |
0.002 |
0.53 (0.36-0.79) |
|
|
||||
|
No |
0 |
|||
|
|
||||
|
Family History IBD |
Yes |
-0.88 |
< 0.0001 |
0.42 (0.30-0.57) |
|
|
||||
|
No |
0 |
|||
|
|
||||
|
NOD2 - rs5743293 |
C |
-1.72 |
0.0002 |
0.18 (0.07-0.44) |
|
|
||||
|
N |
0 |
|||
|
|
||||
|
NOD2 - rs2066844 |
T |
-0.60 |
0.03 |
0.55 (0.33-0.93) |
|
|
||||
|
C |
0 |
|||
|
|
||||
|
NOD2 - rs2066845 |
C |
-1.30 |
0.02 |
0.271 (0.09-0.84) |
|
|
||||
|
G |
0 |
|||
|
|
||||
|
* A positive estimate indicates the variable being more predictive of ulcerative colitis while a negative estimate is more predictive of Crohn's disease. |
||||
|
Kanaan et al. Journal of Negative Results in BioMedicine 2012 11:7 doi:10.1186/1477-5751-11-7 |
||||
