Table 5

Multivariable Logistic Regression Analysis for UC vs. CD

Genetic and Clinical Variables

Ulcerative Colitis vs. Crohn's Disease


Estimate*

p-value

OR (95% CI)


Age at time of diagnosis

≥ 27

0.32

0.04

1.38 (1.02-1.87)


< 27

0


Gender

Female

-0.38

0.01

0.68 (0.50-0.92)


Male

0


Smoker Status

Current

-1.63

< 0.0001

0.20 (0.13-0.30)


Former

-0.81

< 0.0001

0.45 (0.32-0.63)


Never

0

< 0.0001


Number of Operations

Yes

-0.63

0.002

0.53 (0.36-0.79)


No

0


Family History IBD

Yes

-0.88

< 0.0001

0.42 (0.30-0.57)


No

0


NOD2 - rs5743293

C

-1.72

0.0002

0.18 (0.07-0.44)


N

0


NOD2 - rs2066844

T

-0.60

0.03

0.55 (0.33-0.93)


C

0


NOD2 - rs2066845

C

-1.30

0.02

0.271 (0.09-0.84)


G

0


* A positive estimate indicates the variable being more predictive of ulcerative colitis while a negative estimate is more predictive of Crohn's disease.

Kanaan et al. Journal of Negative Results in BioMedicine 2012 11:7   doi:10.1186/1477-5751-11-7

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