Research
Study of the impact of perilipin polymorphisms in a French population
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* Corresponding author: Aline Meirhaeghe Aline.Meirhaeghe-Hurez@pasteur-lille.fr
1 INSERM, U744, Lille; Institut Pasteur de Lille, Lille; Université de Lille 2, Lille, France
2 Department of Epidemiology and Public Health, Faculty of Medicine, Strasbourg, France
3 INSERM, U558, Faculté de Médecine, Toulouse, France
Journal of Negative Results in BioMedicine 2006, 5:10 doi:10.1186/1477-5751-5-10
Published: 12 July 2006Abstract
Background
Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables (anthropometric variables, plasma leptin, lipids, glucose and insulin concentrations) in a cross-sectional random sample of 1120 French men and women aged 35 to 65 years old, including 227 obese (BMI ≥ 30 kg/m2) and 275 type 2 diabetes subjects.
Results
Among 7 perilipin polymorphisms tested, only 2 (rs4578621 and rs894160) of them were frequent enough to be fully investigated and we genotyped the sample using the PCR-RFLP method. No significant associations could be found between any of these polymorphisms and the studied phenotypes.
Conclusion
The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women.