Table 4 |
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|
Impact of the PLIN rs894160 SNP on clinical variables in men and women separately |
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| Men |
Women |
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|
|
|
|||||
| GG 281 |
GA 235 |
AA 54 |
GG 272 |
GA 231 |
AA 39 |
|
|
|
|
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| Weight, kg |
80.2 ± 14.1 |
79.2 ± 12.8 |
81.1 ± 13.2 |
67.5 ± 14.1 |
69.9 ± 14.6 |
67.9 ± 16.8 |
| BMI, kg/m2 |
26.9 ± 4.3 |
26.3 ± 4.0 |
26.3 ± 3.7 |
26.2 ± 5.3 |
27.0 ± 5.4 |
26.7 ± 7.1 |
| Waist, cm |
96.5 ± 11.4 |
95.5 ± 10.2 |
96.3 ± 10.3 |
84.7 ± 13.4 |
87.0 ± 14.1 |
84.3 ± 16.9 |
| Hip circ., cm |
101.7 ± 7.5 |
101.4 ± 7.3 |
101.4 ± 7.1 |
102.9 ± 11.1 |
104.6 ± 11.8 |
103.7 ± 15.5 |
| WHR |
0.95 ± 0.07 |
0.94 ± 0.07 |
0.95 ± 0.07 |
0.82 ± 0.08 |
0.83 ± 0.08 |
0.81 ± 0.07 |
| Leptin, ng/mL† |
9.60 ± 7.90 |
9.18 ± 7.55 |
8.24 ± 6.19 |
23.12 ± 13.72 |
25.26 ± 14.52 |
23.79 ± 13.28 |
|
|
|
|||||
| Cholesterol, mmol/L |
5.93 ± 1.10 |
5.83 ± 1.00 |
5.86 ± 0.90 |
5.90 ± 1.18 |
6.01 ± 1.05 |
5.93 ± 1.11 |
| HDL-chol., mmol/L |
1.33 ± 0.41 |
1.37 ± 0.41 |
1.24 ± 0.37 |
1.65 ± 0.51 |
1.68 ± 0.47 |
1.69 ± 0.43 |
| LDL-chol., mmol/L |
3.90 ± 1.05 |
3.79 ± 0.96 |
3.99 ± 0.85 |
3.69 ± 1.10 |
3.80 ± 0.99 |
3.68 ± 1.05 |
| Triglycerides, mmol/L† |
1.71 ± 1.42 |
1.57 ± 1.31 |
1.68 ± 1.66 |
1.21 ± 0.87 |
1.19 ± 0.97 |
1.16 ± 0.77 |
| Glucose, mmol/L† |
5.56 ± 0.90 |
5.49 ± 0.85 |
5.27 ± 0.64* |
5.40 ± 1.41 |
5.42 ± 1.71 |
5.64 ± 1.55 |
| Insulin, μU/mL† |
12.52 ± 9.48 |
11.93 ± 8.16 |
12.83 ± 13.62 |
11.47 ± 5.86 |
11.83 ± 5.87 |
12.43 ± 7.32 |
|
*crude p < 0.03 or p < 0.04 when adjusted for age, BMI, smoking and alcohol consumptions with a recessive model (adjusted means 5.51 ± 0.05 for GG vs 5.52 ± 0.05 for GA vs 5.28 ± 0.11 for AA subjects). † These variables were log-transformed to obtain normal distributions. Circ. : circumference. WHR : waist-to-hip ratio. Chol. : cholesterol. Among the 1120 individuals genotyped, data on several variables were missing for few subjects. | ||||||
Meirhaeghe et al. Journal of Negative Results in BioMedicine 2006 5:10 doi:10.1186/1477-5751-5-10 |
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