Table 1 |
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Plasma levels of TNF alpha, ghrelin, leptin and adiponectin among healthy male volunteers during short-term intervention with either dexamethasone or placebo. |
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Circulating levels of metabolically active hormones |
Pre-treatment |
Post-treatment |
Significance of the difference between changes (pre-post), Placebo vs. Dexamethasone (p-value) |
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Placebo (n = 12) |
Dexamethasone (n = 13) |
Placebo (n = 12) |
Dexamethasone (n = 13) |
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|
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Insulin sensitivity (HOMA-S)* |
7.55 (6.885–8.85) |
8.28 (7.26–9.85) |
7.07 (6.03–9.96) |
5.46 (4.79–7.39) |
< 0.001 |
|
Insulin sensitivity index (ISI)* |
1.16 (0.81–1.58) |
1.35 (0.95–2.48) |
0.94 (0.53–2.46) |
0.38 (0.26–0.77) |
< 0.001 |
|
Tumor Necrosis Factor alpha (pg/ml) |
660 (230–1580) |
600 (0–1080) |
620 (240– 1460) |
580 (0–1080) |
0.68 |
|
Ghrelin (pg/ml) |
422 (239–591) |
342 (285–497) |
359 (265–465) |
291 (188–347) |
0.19 |
|
Leptin (pg/ml) |
14,400 (8,400–25,600) |
10,700 (4,200–19,800) |
17,800 (2,700–22,600) |
15,900 (4,200–30,500) |
0.85 |
|
Adiponectin (ng/ml) |
460 (270–1380) |
810 (430–2020) |
490 (390–700) |
1420 (910–2120) |
0.17 |
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|
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Median (interquartile range) are shown. A decrease in HOMA-S and ISI is indicative of a reduction in insulin sensitivity. * Changes in insulin sensitivity in this study have been previously reported [12] |
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Patel et al. Journal of Negative Results in BioMedicine 2006 5:14 doi:10.1186/1477-5751-5-14 |
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