Table 1 |
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Sciatic Nerve Conduction Studies in Hexb+/- and Hexb-/- Mice |
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| Hexb+/- |
Hexb-/- |
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| CNCV (m/s)a |
23.6 ± 0.6 (8) |
25.1 ± 0.9 (9) |
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| 100 sec-1 |
400 sec-1 |
600 sec-1 |
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| Percent ΔCNCVa |
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| Hexb+/- |
2% ± 1 (7) |
20% ± 4 (L) (7) |
18% ± 4 (L) (6) |
| 21% ± 4 (S) (7) |
19% ± 3 (S) (6) |
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| Hexb-/- |
5% ± 1 (9)* |
20% ± 2 (L) (9) |
22% ± 3 (L) (8) |
| 22% ± 2 (S) (9) |
22% ± 4 (S) (8) |
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| Wedensky Ratioa |
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| Hexb+/- |
0.99 ± 0.00 (7) |
0.67 ± 0.08 (7) |
0.46 ± 0.09 (6) |
| Hexb-/- |
0.99 ± 0.00 (9) |
0.84 ± 0.03 (9)* |
0.58 ± 0.08 (8) |
| Amplitude Decrease Ratioa |
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| Hexb+/- |
- |
0.54 ± 0.06 (L) (7) |
0.41 ± 0.06 (L) (6) |
| 0.37 ± 0.06 (S) (7) |
0.17 ± 0.02 (S) (6) |
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| Hexb-/- |
- |
0.50 ± 0.03 (L) (9) |
0.39 ± 0.03 (L) (8) |
| 0.42 ± 0.03 (S) (9) |
0.22 ± 0.04 (S) (8) |
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CNCV, compound nerve conduction velocity; Percent ΔCNCV, Wedensky Ratio, Amplitude Decrease Ratio, see Materials and Methods; L, S, see Figure 1 a Values represent the mean ± SEM (n) * p < 0.05 (two-tailed, unpaired t-test), Hexb+/- vs. Hexb-/- |
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McNally et al. Journal of Negative Results in BioMedicine 2007 6:8 doi:10.1186/1477-5751-6-8 |
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