Table 2 |
||
|
Lipid Distribution of Sciatic Nerve in Hexb Micea |
||
| Lipids |
Hexb+/- |
Hexb-/- |
|
|
||
| Total Gangliosides |
44.2 ± 1.2 |
39.7 ± 3.8 |
| (nb = 5) |
(n = 5) |
|
| Individual Gangliosidesc (n = 2) |
||
| GM3 |
2.0, 2.5 |
2.8, 1.9 |
| GM2 |
n.d.d |
1.1, 1.0 |
| LM1 |
1.5, 3.5 |
1.4, 0.8 |
| GM1 |
0.7, 1.4 |
1.8, 1.0 |
| GD3 |
0.6,0.6 |
0.6, 0.8 |
| GD1a |
23.1, 23.9 |
23.8, 19.0 |
| GT1a |
0.3, 0.3 |
1.0, 0.4 |
| GD1b |
1.4, 1.8 |
1.6, 1.5 |
| GT1b |
8.7, 7.7 |
8.6, 7.0 |
| GQ1b |
6.5, 5.1 |
5.1, 4.5 |
| Neutral |
||
| Triglycerides |
38.2 ± 2.4 |
43.6 ± 5.0 |
| Cholesterol |
9.9 ± 1.2 |
11.4 ± 1.5 |
| Cerebrosides |
6.6 ± 0.5 |
6.7 ± 0.4 |
| Phosphatidylethanolamine |
5.4 ± 0.4 |
6.0 ± 0.4 |
| Phosphatidylcholine |
4.3 ± 0.3 |
3.8 ± 0.2 |
| Sphingomyelin |
2.6 ± 0.3 |
2.4 ± 0.4 |
| (n = 6) |
(n = 6) |
|
| Acidic |
||
| Sulfatides |
1.4 ± 0.1 |
1.4 ± 0.1 |
| Phosphatidylserine |
3.2 ± 0.3 |
3.1 ± 0.1 |
| Phosphatidylinositol |
0.4 ± 0.0 |
0.4 ± 0.0 |
| (n = 5) |
(n = 6) |
|
|
|
||
|
a Values are expressed as mean ± SEM in mg/100 mg dry weight (neutral, acidic) or μg sialic acid/100 mg dry weight (ganglioside). b n, the number of independent samples analyzed. (6–8 sciatic nerves were pooled per independent sample) c due to small amounts of gangliosides present in tissue, only two samples were obtained for analysis d n.d., not detected |
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|
McNally et al. Journal of Negative Results in BioMedicine 2007 6:8 doi:10.1186/1477-5751-6-8 |
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