Research
Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients
1 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Republic of China
2 Department of Pediatrics, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, Republic of China
3 National Yang-Ming University, Taipei, Taiwan, Republic of China
4 Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China
5 Section of Infection Diseases, Taipei Municipal Zen Ai Hospital, Taipei, Taiwan, Republic of China
6 Section of Infection Diseases, Mackay Memorial Hospital Taitung Branch, Taitung, Taiwan, Republic of China
7 Division of Infectious Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China
8 Section of Infection Diseases, Tainan Municipal Hospital, Tainan, Taiwan, Republic of China
9 Section of Infection Diseases, Kaohsiung Medical College Chung-Ho Memorial Hospital, Kaohsiung, Taiwan, Republic of China
10 Section of Infection Diseases, Buddhist, Tzu-Chi General Hospital, Hualien, Taiwan, Republic of China
11 Section of Infection Diseases, Veterans General Hospital-Taichung, Taipei, Taiwan, Republic of China
12 Department of Hematology and Oncology, Chang-Gung Memorial Hospital-Chiayi, Chiayi, Taiwan, Republic of China
Journal of Negative Results in BioMedicine 2008, 7:12 doi:10.1186/1477-5751-7-12
Published: 16 December 2008Abstract
Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and other antifungal drugs. The medical records of 88 patients, colonized or infected with Candida species, from nine of the 22 hospitals that provided clinical isolates to the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program in 1999 were reviewed. A total of 35 patients contributed fluconazole resistant strains [minimum inhibitory concentrations (MICs) ≧ 64 mg/l], while the remaining 53 patients contributed susceptible ones (MICs ≦ 8 mg/l). Fluconazole resistance was more frequent among isolates of Candida tropicalis (46.5%) than either C. albicans (36.8%) or C. glabrata (30.8%). There was no significant difference in demographic characteristics or underlying diseases among patients contributing strains different in drug susceptibility.
