Research

Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany

Qumar Parwez¹ , Susanne Stemmler² , Jörg T Epplen² and Sabine Hoffjan²

¹  Private medical practice, Gladbeck, Germany

²  Department of Human Genetics, Ruhr-University, Bochum, Germany

author email corresponding author email

Journal of Negative Results in BioMedicine 2008, 7:9doi:10.1186/1477-5751-7-9

Published:	13 November 2008

Abstract

Background

Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls.

Results

Genotype and allele frequencies did not differ between patients and controls for all polymorphisms investigated in this study. Haplotype analysis did not reveal any additional information.

Conclusion

We did not find evidence to support an influence of variation in genes encoding eosinophil granule proteins for AD pathogenesis in this German cohort.