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Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity
Junaid Iqbal, Mehak Rajani, Ruqaiyyah Siddiqui, Naveed Ahmed Khan Journal of Negative Results in BioMedicine 2013, 12:8 (1 May 2013)
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Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation
Andreas Kuehnl, Jaroslav Pelisek, Martin Bruckmeier, Wajima Safi, Hans-Henning Eckstein Journal of Negative Results in BioMedicine 2013, 12:7 (1 April 2013)
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Exclusion of eleven candidate genes for ocular melanosis in cairn terriers
Paige A Winkler, Joshua T Bartoe, Celeste R Quinones, Patrick J Venta, Simon M Petersen-Jones Journal of Negative Results in BioMedicine 2013, 12:6 (1 March 2013)
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Editor’s summary
The genotyping of eleven candidate genes for Ocular Melanosis in Cairn Terriers suggests they are unlikely to be the gene locus for this condition, highlighting the need for further study.
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Circulating rotaviral RNA in children with rotavirus antigenemia
Kamruddin Ahmed, Gulendam Bozdayi, Marcelo T Mitui, Selim Ahmed, Luthful Kabir, Dalgic Buket, Ilknur Bostanci, Akira Nishizono Journal of Negative Results in BioMedicine 2013, 12:5 (1 February 2013)
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Editor’s summary
Rotavirus (RVA) viremia was not found in children with rotavirus diarrhea, and could not be identified via the presence of antigenemia in the patients’ serum.
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Prolactin gene expression in primary central nervous system tumors
Graziella Alebrant Mendes, Júlia Fernanda Semmelmann Pereira-Lima, Maria Beatriz Kohek, Geraldine Trott, Marlise Di Domenico, Nelson Pires Ferreira, Miriam da Costa Oliveira Journal of Negative Results in BioMedicine 2013, 12:4 (14 January 2013)
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Quantitative real-time polymerase chain reaction (PCR-RT) did not show prolactin expression in primary central nervous system tumors, suggesting that its presence is not a reflex of local production.
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Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods
R Brad Jones, Fabio E Leal, Aaron M Hasenkrug, Aluisio C Segurado, Douglas F Nixon, Mario A Ostrowski, Esper G Kallas Journal of Negative Results in BioMedicine 2013, 12:3 (10 January 2013)
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The elicitation of human endogenous retrovirus (HERV)-specific T-cells responses may not have a role in human T-cell leukemia virus type 1 (HTLV-1) associated immunopathology suggests this study.
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Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis
Luis P Andrade, Stewart M Rhind, Michael T Rae, Carol E Kyle, Jamie Jowett, Richard G Lea Journal of Negative Results in BioMedicine 2013, 12:2 (8 January 2013)
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A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen Journal of Negative Results in BioMedicine 2013, 12:1 (2 January 2013)
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Absence of subtelomeric rearrangements in selected patients with mental retardation as assessed by multiprobe T FISH
Suely Rodrigues dos Santos, Dértia Villalba Freire-Maia Journal of Negative Results in BioMedicine 2012, 11:16 (21 December 2012)
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Editor’s summary
Patients with unexplained mental retardation (MR) and a chromosomal imbalance show an absence of subtelomeric rearrangements when assessed by Multiprobe T Fluorescence In-Situ Hybridization (MT FISH) probe.
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Could titanium oxide coating from a sol–gel process make stone baskets more resistant to laser radiation at 2.1 μm?
Jens Cordes, Felix Nguyen, Frank Heidenau, Dieter Jocham Journal of Negative Results in BioMedicine 2012, 11:15 (19 October 2012)
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Editor’s summary
The first attempt at making stone baskets more resistant to laser damage during endoscopic surgery did not result in greater resistance to laser radiation at 2.1 mum.
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Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury
Inga Karu, Peeter Tähepõld, Arno Ruusalepp, Kersti Zilmer, Mihkel Zilmer, Joel Starkopf Journal of Negative Results in BioMedicine 2012, 11:14 (14 September 2012)
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Editor’s summary
Pre-treatment with hyperoxia followed by normoxia before coronary artery bypass grafting does not protect against myocardial injury.
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No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial
Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg, Ansgar Espeland Journal of Negative Results in BioMedicine 2012, 11:13 (17 August 2012)
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In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats
Marcos Contó, Marco Antonio Venditti Journal of Negative Results in BioMedicine 2012, 11:12 (10 May 2012)
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Editor’s summary
A better understanding is needed of the relationship between glutamatergic activation and enzymatic activity, suggests this study which finds that glutamatergic stimulation in rats does not influence Na+,K+-ATPase activity in the frontal lobe, the inhibition of which is associated with pathogenesis of epilepsy.
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Lifestyle counseling during pregnancy and offspring weight development until four years of age: follow-up study of a controlled trial
Taina Mustila, Jani Raitanen, Päivi Keskinen, Antti Saari, Riitta Luoto Journal of Negative Results in BioMedicine 2012, 11:11 (8 May 2012)
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Gestational lifestyle counseling does not significantly slow weight gain, proposes this pilot study which investigates risk of childhood obesity.
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Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE2 production by human gingival fibroblasts
Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori, Hiroo Miyazawa Journal of Negative Results in BioMedicine 2012, 11:10 (27 March 2012)
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Editor’s summary
Commonly prescribed for bronchial disorders, aminophylline does not adversely affect inflammatory response and exacerbate symptoms in periodontal disease at concentrations used in clinical settings unlike other PKA-inhibiting drugs.
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TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome
Krishna K Singh, Joerg Schmidtke, Britta Keyser, Mine Arslan-Kirchner Journal of Negative Results in BioMedicine 2012, 11:9 (2 February 2012)
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Metallothionein genes: no association with Crohn's disease in a New Zealand population
Angharad R Morgan, Alan G Fraser, Lynnette R Ferguson Journal of Negative Results in BioMedicine 2012, 11:8 (28 January 2012)
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Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population
Ziad M Kanaan, Maurice R Eichenberger, Surriya Ahmad, Clayton Weller, Henry Roberts, Jianmin Pan, Shesh N Rai, Robert Petras, E Brooks Weller, Susan Galandiuk Journal of Negative Results in BioMedicine 2012, 11:7 (23 January 2012)
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Editor’s summary
There is no association between OCTN1 and IGR SNPs and IBD (Inflammatory Bowel Disease), suggests this study which proposes a combined genetic, phenotypic and environmental approach to understand IBD.
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Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players
Yongwoo Jang, Sung Min Kim Journal of Negative Results in BioMedicine 2012, 11:6 (12 January 2012)
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Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen, Yen-Ching Chen Journal of Negative Results in BioMedicine 2012, 11:5 (12 January 2012)
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A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy
Diogo G Biagi, José G Mill, Alfredo J Mansur, José E Krieger, Alexandre C Pereira Journal of Negative Results in BioMedicine 2012, 11:4 (11 January 2012)
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5-Azacytidine Is Insufficient For Cardiogenesis In Human Adipose-Derived Stem Cells
Wan Kamarul Zaman Wan Safwani, Suzana Makpol, Somasundaram Sathapan, Kien Chua Journal of Negative Results in BioMedicine 2012, 11:3 (6 January 2012)
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Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer
Panagiotis J Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, Kassiani Kapatou, Ioannis Gioulbasanis, Danai D Daliani, George Moutzouris, Christos N Papandreou Journal of Negative Results in BioMedicine 2012, 11:2 (5 January 2012)
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The female menstrual cycle does not influence testosterone concentrations in male partners
Jakob O Strom, Edvin Ingberg, Emma Druvefors, Annette Theodorsson, Elvar Theodorsson Journal of Negative Results in BioMedicine 2012, 11:1 (3 January 2012)
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Editor’s summary
The hypothesis that male testosterone concentrations increase with female olfactory ovulation cues is contradicted in a study which monitored thirty couples and established no significant effect, also suggesting no relevance of ovulation to male sexual drive and aggressiveness.
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Diagnosis of tuberculosis: the experience at a specialized diagnostic laboratory
Anita Mashta, Pooja Mishra, Sonia Philipose, S Tamilzhalagan, Hanif Mahmud, Sangeeta Bhaskar, Pramod Upadhyay Journal of Negative Results in BioMedicine 2011, 10:16 (18 November 2011)
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Lipoprotein(a) and inflammation in patients with atrial fibrillation after electrical cardioversion
Franjo Naji, Miso Sabovic Journal of Negative Results in BioMedicine 2011, 10:15 (12 November 2011)
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Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis
Raquel M Scarel-Caminaga, Karen MC Curtis, Rivelto Renzi, Patrícia M Sogumo, Giovana Anovazzi, Aline C Viana, Yeon J Kim, Silvana RP Orrico, Joni A Cirelli Journal of Negative Results in BioMedicine 2011, 10:14 (3 November 2011)
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Applying the Stages of Change model to Type 2 diabetes care in Trinidad: A randomised trial
VA Partapsingh, RG Maharaj, JM Rawlins Journal of Negative Results in BioMedicine 2011, 10:13 (11 October 2011)
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The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study
Paula L Hedley, Ole Haundrup, Paal S Andersen, Frederik H Aidt, Morten Jensen, Johanna C Moolman-Smook, Henning Bundgaard, Michael Christiansen Journal of Negative Results in BioMedicine 2011, 10:12 (3 October 2011)
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Retroperitoneoscopic radical nephrectomy with a small incision for renal cell carcinoma: Comparison with the conventional method
Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Futoshi Sano, Takayuki Murakami, Narihiko Hayashi, Yasuhide Miyoshi, Noboru Nakaigawa, Masahiro Yao, Yoshinobu Kubota Journal of Negative Results in BioMedicine 2011, 10:11 (16 August 2011)
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False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia
Saengchan Senapin, Kornsunee Phiwsaiya, Warachin Gangnonngiw, Timothy W Flegel Journal of Negative Results in BioMedicine 2011, 10:10 (3 August 2011)
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Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration
Marina Klawitter, Lilian Quero, Alessando Bertolo, Marco Mehr, Jivko Stoyanov, Andreas G Nerlich, Juergen Klasen, Nikolaus Aebli, Norbert Boos, Karin Wuertz Journal of Negative Results in BioMedicine 2011, 10:9 (29 July 2011)
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Gastrointestinal complaints in runners are not due to small intestinal bacterial overgrowth
Kai Schommer, Dejan Reljic, Peter Bärtsch, Peter Sauer Journal of Negative Results in BioMedicine 2011, 10:8 (27 July 2011)
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Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts
David W Ellison, Mehmet Kocak, Dominique Figarella-Branger, Giangaspero Felice, Godfraind Catherine, Torsten Pietsch, Didier Frappaz, Maura Massimino, Jacques Grill, James M Boyett, Richard G Grundy Journal of Negative Results in BioMedicine 2011, 10:7 (31 May 2011)
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No connection between the level of exposition to statins in the population and the incidence/mortality of acute myocardial infarction: An ecological study based on Sweden's municipalities
Staffan Nilsson, Sigvard Mölstad, Catarina Karlberg, Jan-Erik Karlsson, Lars-Göran Persson Journal of Negative Results in BioMedicine 2011, 10:6 (24 May 2011)
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N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
Mutien-Marie O Garigliany, Daniel J Desmecht Journal of Negative Results in BioMedicine 2011, 10:5 (9 May 2011)
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The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes
Amélie Dendooven, Tri Q Nguyen, Lodewijk Brosens, Dongxia Li, Lise Tarnow, Hans-Henrik Parving, Peter Rossing, Roel Goldschmeding Journal of Negative Results in BioMedicine 2011, 10:4 (8 May 2011)
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Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece
Chrissa Sioka, Stylianos Papakonstantinou, Sofia Markoula, Foteini Gkartziou, Athanasia Georgiou, Ioannis Georgiou, Sygliti-Henrietta Pelidou, Athanassios P Kyritsis, Andreas Fotopoulos Journal of Negative Results in BioMedicine 2011, 10:3 (5 May 2011)
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Validity of self-reported leisure-time sedentary behavior in adolescents
Olivia Affuso, June Stevens, Diane Catellier, Robert G McMurray, Dianne S Ward, Leslie Lytle, Melinda S Sothern, Deborah R Young Journal of Negative Results in BioMedicine 2011, 10:2 (11 February 2011)
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Editor’s summary
Adolescents generally underestimated the duration of their sedentary behavior compared to data obtained objectively using an accelerometer, a movement monitor capturing the intensity of physical activity, questioning the reliability of activity-based questionnaires in public health research.
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Methylphenidate for treating tobacco dependence in non-attention deficit hyperactivity disorder smokers: A pilot randomized placebo-controlled trial
Richard D Hurt, Jon O Ebbert, Ivana T Croghan, Darrell R Schroeder, Amit Sood, J Taylor Hays Journal of Negative Results in BioMedicine 2011, 10:1 (28 January 2011)
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Editor’s summary
Despite similarities in neuropsychologic effects between nicotine and methylphenidate, the first large trial of the psychostimulant in non-ADHD smokers showed neither an increase in smoking abstinence, nor any observed effect on smoking rates and tobacco withdrawal symptoms.
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The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)
Kathrin Scheckenbach, Galatia Papadopoulou, Thomas K Hoffmann, Adam Chaker, Henning Bier, Jörg Schipper, Vera Balz, Martin Wagenmann Journal of Negative Results in BioMedicine 2010, 9:10 (25 December 2010)
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TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
Magda A Blaut, Natalia V Bogdanova, Michael Bremer, Johann H Karstens, Peter Hillemanns, Thilo Dörk Journal of Negative Results in BioMedicine 2010, 9:9 (25 November 2010)
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Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes
Lenka Sarnova, Radek Malik, Radislav Sedlacek, Petr Svoboda Journal of Negative Results in BioMedicine 2010, 9:8 (12 October 2010)
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Generation of a panel of antibodies against proteins encoded on human chromosome 21
Frances K Wiseman, Olivia Sheppard, Jacqueline M Linehan, Sebastian Brandner, Victor LJ Tybulewicz, Elizabeth MC Fisher Journal of Negative Results in BioMedicine 2010, 9:7 (20 August 2010)
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A comparison of meningococcal carriage by pregnancy status
Eric J Knudtson, Mike L Lytle, Beverly A Vavricka, Valerie S Skaggs, Jennifer D Peck, Andrew E Elimian Journal of Negative Results in BioMedicine 2010, 9:6 (11 August 2010)
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The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton
Ronald R Dubreuil, Amlan Das, Christine Base, G Harper Mazock Journal of Negative Results in BioMedicine 2010, 9:5 (23 June 2010)
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Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1
Bruno R Souza, Karen CL Torres, Débora M Miranda, Bernardo S Motta, Estêvão Scotti-Muzzi, Melissa M Guimarães, Daniel S Carneiro, Daniela VF Rosa, Renan P Souza, Helton J Reis, Andreas Jeromin, Marco A Romano-Silva Journal of Negative Results in BioMedicine 2010, 9:4 (19 June 2010)
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Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats
Rosimary S Carvalho, Carolina M de Souza, Julliana CS Neves, Sergio A Holanda-Pinto, Lívia MS Pinto, Gerly AC Brito, Geanne M de Andrade Journal of Negative Results in BioMedicine 2010, 9:3 (14 June 2010)
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Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter-driven gene expression
Zoe Redshaw, Alastair J Strain Journal of Negative Results in BioMedicine 2010, 9:2 (31 March 2010)
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Does computer use pose a hazard for future long-term sickness absence?
Johan H Andersen, Sigurd Mikkelsen Journal of Negative Results in BioMedicine 2010, 9:1 (22 March 2010)
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