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Brief report   Open Access

Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity

Junaid Iqbal, Mehak Rajani, Ruqaiyyah Siddiqui, Naveed Ahmed Khan Journal of Negative Results in BioMedicine 2013, 12:8 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

Brief report   Open Access

Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation

Andreas Kuehnl, Jaroslav Pelisek, Martin Bruckmeier, Wajima Safi, Hans-Henning Eckstein Journal of Negative Results in BioMedicine 2013, 12:7 (1 April 2013)

Abstract | Full text | PDF | PubMed

Research   Open Access

Exclusion of eleven candidate genes for ocular melanosis in cairn terriers

Paige A Winkler, Joshua T Bartoe, Celeste R Quinones, Patrick J Venta, Simon M Petersen-Jones Journal of Negative Results in BioMedicine 2013, 12:6 (1 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The genotyping of eleven candidate genes for Ocular Melanosis in Cairn Terriers suggests they are unlikely to be the gene locus for this condition, highlighting the need for further study.

Research   Open Access

Circulating rotaviral RNA in children with rotavirus antigenemia

Kamruddin Ahmed, Gulendam Bozdayi, Marcelo T Mitui, Selim Ahmed, Luthful Kabir, Dalgic Buket, Ilknur Bostanci, Akira Nishizono Journal of Negative Results in BioMedicine 2013, 12:5 (1 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Rotavirus (RVA) viremia was not found in children with rotavirus diarrhea, and could not be identified via the presence of antigenemia in the patients’ serum.

Research   Open Access

Prolactin gene expression in primary central nervous system tumors

Graziella Alebrant Mendes, Júlia Fernanda Semmelmann Pereira-Lima, Maria Beatriz Kohek, Geraldine Trott, Marlise Di Domenico, Nelson Pires Ferreira, Miriam da Costa Oliveira Journal of Negative Results in BioMedicine 2013, 12:4 (14 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Quantitative real-time polymerase chain reaction (PCR-RT) did not show prolactin expression in primary central nervous system tumors, suggesting that its presence is not a reflex of local production.

Research   Open Access

Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods

R Brad Jones, Fabio E Leal, Aaron M Hasenkrug, Aluisio C Segurado, Douglas F Nixon, Mario A Ostrowski, Esper G Kallas Journal of Negative Results in BioMedicine 2013, 12:3 (10 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The elicitation of human endogenous retrovirus (HERV)-specific T-cells responses may not have a role in human T-cell leukemia virus type 1 (HTLV-1) associated immunopathology suggests this study.

Research   Open Access

Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis

Luis P Andrade, Stewart M Rhind, Michael T Rae, Carol E Kyle, Jamie Jowett, Richard G Lea Journal of Negative Results in BioMedicine 2013, 12:2 (8 January 2013)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen Journal of Negative Results in BioMedicine 2013, 12:1 (2 January 2013)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

Absence of subtelomeric rearrangements in selected patients with mental retardation as assessed by multiprobe T FISH

Suely Rodrigues dos Santos, Dértia Villalba Freire-Maia Journal of Negative Results in BioMedicine 2012, 11:16 (21 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients with unexplained mental retardation (MR) and a chromosomal imbalance show an absence of subtelomeric rearrangements when assessed by Multiprobe T Fluorescence In-Situ Hybridization (MT FISH) probe.

Research   Open Access

Could titanium oxide coating from a sol–gel process make stone baskets more resistant to laser radiation at 2.1 μm?

Jens Cordes, Felix Nguyen, Frank Heidenau, Dieter Jocham Journal of Negative Results in BioMedicine 2012, 11:15 (19 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The first attempt at making stone baskets more resistant to laser damage during endoscopic surgery did not result in greater resistance to laser radiation at 2.1 mum.

Research   Open Access

Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury

Inga Karu, Peeter Tähepõld, Arno Ruusalepp, Kersti Zilmer, Mihkel Zilmer, Joel Starkopf Journal of Negative Results in BioMedicine 2012, 11:14 (14 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Pre-treatment with hyperoxia followed by normoxia before coronary artery bypass grafting does not protect against myocardial injury.

Research   Open Access

No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial

Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg, Ansgar Espeland Journal of Negative Results in BioMedicine 2012, 11:13 (17 August 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats

Marcos Contó, Marco Antonio Venditti Journal of Negative Results in BioMedicine 2012, 11:12 (10 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A better understanding is needed of the relationship between glutamatergic activation and enzymatic activity, suggests this study which finds that glutamatergic stimulation in rats does not influence Na+,K+-ATPase activity in the frontal lobe, the inhibition of which is associated with pathogenesis of epilepsy.

Research   Open Access Highly Accessed

Lifestyle counseling during pregnancy and offspring weight development until four years of age: follow-up study of a controlled trial

Taina Mustila, Jani Raitanen, Päivi Keskinen, Antti Saari, Riitta Luoto Journal of Negative Results in BioMedicine 2012, 11:11 (8 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gestational lifestyle counseling does not significantly slow weight gain, proposes this pilot study which investigates risk of childhood obesity.

Research   Open Access Highly Accessed

Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE2 production by human gingival fibroblasts

Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori, Hiroo Miyazawa Journal of Negative Results in BioMedicine 2012, 11:10 (27 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commonly prescribed for bronchial disorders, aminophylline does not adversely affect inflammatory response and exacerbate symptoms in periodontal disease at concentrations used in clinical settings unlike other PKA-inhibiting drugs.

Research   Open Access

TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome

Krishna K Singh, Joerg Schmidtke, Britta Keyser, Mine Arslan-Kirchner Journal of Negative Results in BioMedicine 2012, 11:9 (2 February 2012)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

Metallothionein genes: no association with Crohn's disease in a New Zealand population

Angharad R Morgan, Alan G Fraser, Lynnette R Ferguson Journal of Negative Results in BioMedicine 2012, 11:8 (28 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population

Ziad M Kanaan, Maurice R Eichenberger, Surriya Ahmad, Clayton Weller, Henry Roberts, Jianmin Pan, Shesh N Rai, Robert Petras, E Brooks Weller, Susan Galandiuk Journal of Negative Results in BioMedicine 2012, 11:7 (23 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

There is no association between OCTN1 and IGR SNPs and IBD (Inflammatory Bowel Disease), suggests this study which proposes a combined genetic, phenotypic and environmental approach to understand IBD.

Research   Open Access

Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players

Yongwoo Jang, Sung Min Kim Journal of Negative Results in BioMedicine 2012, 11:6 (12 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease

Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen, Yen-Ching Chen Journal of Negative Results in BioMedicine 2012, 11:5 (12 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy

Diogo G Biagi, José G Mill, Alfredo J Mansur, José E Krieger, Alexandre C Pereira Journal of Negative Results in BioMedicine 2012, 11:4 (11 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

5-Azacytidine Is Insufficient For Cardiogenesis In Human Adipose-Derived Stem Cells

Wan Kamarul Zaman Wan Safwani, Suzana Makpol, Somasundaram Sathapan, Kien Chua Journal of Negative Results in BioMedicine 2012, 11:3 (6 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer

Panagiotis J Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, Kassiani Kapatou, Ioannis Gioulbasanis, Danai D Daliani, George Moutzouris, Christos N Papandreou Journal of Negative Results in BioMedicine 2012, 11:2 (5 January 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

The female menstrual cycle does not influence testosterone concentrations in male partners

Jakob O Strom, Edvin Ingberg, Emma Druvefors, Annette Theodorsson, Elvar Theodorsson Journal of Negative Results in BioMedicine 2012, 11:1 (3 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The hypothesis that male testosterone concentrations increase with female olfactory ovulation cues is contradicted in a study which monitored thirty couples and established no significant effect, also suggesting no relevance of ovulation to male sexual drive and aggressiveness.

Research   Open Access Highly Accessed

Diagnosis of tuberculosis: the experience at a specialized diagnostic laboratory

Anita Mashta, Pooja Mishra, Sonia Philipose, S Tamilzhalagan, Hanif Mahmud, Sangeeta Bhaskar, Pramod Upadhyay Journal of Negative Results in BioMedicine 2011, 10:16 (18 November 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Lipoprotein(a) and inflammation in patients with atrial fibrillation after electrical cardioversion

Franjo Naji, Miso Sabovic Journal of Negative Results in BioMedicine 2011, 10:15 (12 November 2011)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Raquel M Scarel-Caminaga, Karen MC Curtis, Rivelto Renzi, Patrícia M Sogumo, Giovana Anovazzi, Aline C Viana, Yeon J Kim, Silvana RP Orrico, Joni A Cirelli Journal of Negative Results in BioMedicine 2011, 10:14 (3 November 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Applying the Stages of Change model to Type 2 diabetes care in Trinidad: A randomised trial

VA Partapsingh, RG Maharaj, JM Rawlins Journal of Negative Results in BioMedicine 2011, 10:13 (11 October 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study

Paula L Hedley, Ole Haundrup, Paal S Andersen, Frederik H Aidt, Morten Jensen, Johanna C Moolman-Smook, Henning Bundgaard, Michael Christiansen Journal of Negative Results in BioMedicine 2011, 10:12 (3 October 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Retroperitoneoscopic radical nephrectomy with a small incision for renal cell carcinoma: Comparison with the conventional method

Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Futoshi Sano, Takayuki Murakami, Narihiko Hayashi, Yasuhide Miyoshi, Noboru Nakaigawa, Masahiro Yao, Yoshinobu Kubota Journal of Negative Results in BioMedicine 2011, 10:11 (16 August 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia

Saengchan Senapin, Kornsunee Phiwsaiya, Warachin Gangnonngiw, Timothy W Flegel Journal of Negative Results in BioMedicine 2011, 10:10 (3 August 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration

Marina Klawitter, Lilian Quero, Alessando Bertolo, Marco Mehr, Jivko Stoyanov, Andreas G Nerlich, Juergen Klasen, Nikolaus Aebli, Norbert Boos, Karin Wuertz Journal of Negative Results in BioMedicine 2011, 10:9 (29 July 2011)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

Gastrointestinal complaints in runners are not due to small intestinal bacterial overgrowth

Kai Schommer, Dejan Reljic, Peter Bärtsch, Peter Sauer Journal of Negative Results in BioMedicine 2011, 10:8 (27 July 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts

David W Ellison, Mehmet Kocak, Dominique Figarella-Branger, Giangaspero Felice, Godfraind Catherine, Torsten Pietsch, Didier Frappaz, Maura Massimino, Jacques Grill, James M Boyett, Richard G Grundy Journal of Negative Results in BioMedicine 2011, 10:7 (31 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access Highly Accessed

No connection between the level of exposition to statins in the population and the incidence/mortality of acute myocardial infarction: An ecological study based on Sweden's municipalities

Staffan Nilsson, Sigvard Mölstad, Catarina Karlberg, Jan-Erik Karlsson, Lars-Göran Persson Journal of Negative Results in BioMedicine 2011, 10:6 (24 May 2011)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

N-acetylcysteine lacks universal inhibitory activity against influenza A viruses

Mutien-Marie O Garigliany, Daniel J Desmecht Journal of Negative Results in BioMedicine 2011, 10:5 (9 May 2011)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes

Amélie Dendooven, Tri Q Nguyen, Lodewijk Brosens, Dongxia Li, Lise Tarnow, Hans-Henrik Parving, Peter Rossing, Roel Goldschmeding Journal of Negative Results in BioMedicine 2011, 10:4 (8 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access Highly Accessed

Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece

Chrissa Sioka, Stylianos Papakonstantinou, Sofia Markoula, Foteini Gkartziou, Athanasia Georgiou, Ioannis Georgiou, Sygliti-Henrietta Pelidou, Athanassios P Kyritsis, Andreas Fotopoulos Journal of Negative Results in BioMedicine 2011, 10:3 (5 May 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Validity of self-reported leisure-time sedentary behavior in adolescents

Olivia Affuso, June Stevens, Diane Catellier, Robert G McMurray, Dianne S Ward, Leslie Lytle, Melinda S Sothern, Deborah R Young Journal of Negative Results in BioMedicine 2011, 10:2 (11 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Adolescents generally underestimated the duration of their sedentary behavior compared to data obtained objectively using an accelerometer, a movement monitor capturing the intensity of physical activity, questioning the reliability of activity-based questionnaires in public health research.

Research   Open Access

Methylphenidate for treating tobacco dependence in non-attention deficit hyperactivity disorder smokers: A pilot randomized placebo-controlled trial

Richard D Hurt, Jon O Ebbert, Ivana T Croghan, Darrell R Schroeder, Amit Sood, J Taylor Hays Journal of Negative Results in BioMedicine 2011, 10:1 (28 January 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Despite similarities in neuropsychologic effects between nicotine and methylphenidate, the first large trial of the psychostimulant in non-ADHD smokers showed neither an increase in smoking abstinence, nor any observed effect on smoking rates and tobacco withdrawal symptoms.

Research   Open Access

The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)

Kathrin Scheckenbach, Galatia Papadopoulou, Thomas K Hoffmann, Adam Chaker, Henning Bier, Jörg Schipper, Vera Balz, Martin Wagenmann Journal of Negative Results in BioMedicine 2010, 9:10 (25 December 2010)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study

Magda A Blaut, Natalia V Bogdanova, Michael Bremer, Johann H Karstens, Peter Hillemanns, Thilo Dörk Journal of Negative Results in BioMedicine 2010, 9:9 (25 November 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes

Lenka Sarnova, Radek Malik, Radislav Sedlacek, Petr Svoboda Journal of Negative Results in BioMedicine 2010, 9:8 (12 October 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

Generation of a panel of antibodies against proteins encoded on human chromosome 21

Frances K Wiseman, Olivia Sheppard, Jacqueline M Linehan, Sebastian Brandner, Victor LJ Tybulewicz, Elizabeth MC Fisher Journal of Negative Results in BioMedicine 2010, 9:7 (20 August 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

A comparison of meningococcal carriage by pregnancy status

Eric J Knudtson, Mike L Lytle, Beverly A Vavricka, Valerie S Skaggs, Jennifer D Peck, Andrew E Elimian Journal of Negative Results in BioMedicine 2010, 9:6 (11 August 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton

Ronald R Dubreuil, Amlan Das, Christine Base, G Harper Mazock Journal of Negative Results in BioMedicine 2010, 9:5 (23 June 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1

Bruno R Souza, Karen CL Torres, Débora M Miranda, Bernardo S Motta, Estêvão Scotti-Muzzi, Melissa M Guimarães, Daniel S Carneiro, Daniela VF Rosa, Renan P Souza, Helton J Reis, Andreas Jeromin, Marco A Romano-Silva Journal of Negative Results in BioMedicine 2010, 9:4 (19 June 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats

Rosimary S Carvalho, Carolina M de Souza, Julliana CS Neves, Sergio A Holanda-Pinto, Lívia MS Pinto, Gerly AC Brito, Geanne M de Andrade Journal of Negative Results in BioMedicine 2010, 9:3 (14 June 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter-driven gene expression

Zoe Redshaw, Alastair J Strain Journal of Negative Results in BioMedicine 2010, 9:2 (31 March 2010)

Abstract | Full text | PDF | PubMed

Brief report   Open Access

Does computer use pose a hazard for future long-term sickness absence?

Johan H Andersen, Sigurd Mikkelsen Journal of Negative Results in BioMedicine 2010, 9:1 (22 March 2010)

Abstract | Full text | PDF | PubMed

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