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The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes

Amélie Dendooven1, Tri Q Nguyen1, Lodewijk Brosens1, Dongxia Li2, Lise Tarnow3, Hans-Henrik Parving4, Peter Rossing3 and Roel Goldschmeding1*

Author Affiliations

1 Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands

2 FibroGen Inc, 409 Illinois St. San Francisco, CA 94158 USA

3 Steno Diabetes Center, A/S Niels Steensens Vej 2, DK-2820 Gentofte, Denmark

4 Department of Endocrinology, Rigshospitalet University Hospital, Blegdamsvej 9, DK - 2100 Copenhagen, Denmark

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Journal of Negative Results in BioMedicine 2011, 10:4  doi:10.1186/1477-5751-10-4

Published: 8 May 2011

Abstract

The -945GC polymorphism (rs6918698) in the connective tissue growth factor gene promoter (CTGF/CCN-2) has been associated with end organ damage in systemic sclerosis. Because CTGF is important in progression of diabetic kidney disease, we investigated whether the -945GC polymorphism is associated with plasma CTGF level and outcome in type 1 diabetes.

The study cohort consisted of 448 diabetic nephropathy patients and 419 normoalbuminuric diabetic patients with complete data concerning renal function and cardiovascular characteristics. Genomic DNA was genotyped by a QPCR-based SNP assay. We observed no relation between the -945GC polymorphism and plasma CTGF level, and the genotype frequencies were not different in nephropathy patients vs. normoalbuminuric controls. General and cardiovascular mortality, and renal function decline was similar in patients with CC, CG or GG genotypes.

In conclusion, the -945GC SNP does not affect plasma CTGF levels, incidence and prognosis of diabetic nephropathy, and cardiovascular outcome.