Research

Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance

Sushila Jaiswal , Vinita Agrawal , Awadhesh Kumar Jaiswal , Rakesh Pandey and Ashok Kumar Mahapatra

Department of Pathology and Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India

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Journal of Negative Results in BioMedicine 2009, 8:9doi:10.1186/1477-5751-8-9

Published:	4 November 2009

Abstract

Objective

The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.

Materials and methods

The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009. The clinical details were noted from the medical case files. Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.

Results

Neither estrogen nor progesterone receptors could be detected in any of our cases by means of well known immunohistochemical method using well documented monoclonal antibodies. In the control specimens, a strongly positive reaction could be seen.

Conclusion

No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas. Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.